As an experiment , I guess it should work, but Im guessing BG2 is too heavy of a game for Dosbox. Not even the simplest 3d games are playable under Win95/98 at semidecent framerates, and BG2 is quite demanding for being a Dos 2d game. Im curious about how this will run.
Just to share some info, aside using dosbox, there is a VERY good EE port or you can play using an infinity engine emulator on Android (gemrb).
ps: Ive never tried using images over 2gb… cant help much there, sorry.