Hi, hard to say without having the game for testing. Master of Orion is common and often played with Magic dosbox. In situations like this is often problem in sound configuration. Yes, try disable sound in game configuration first and give it a try. Or run autodetection. Let machine at default value. I don’t have MoO by hand, but it should have setup.exe in game folder.
And at the end you can try pure installaion process. This should help at 99%:) Let me know