seems this game suffers the same issue like Albion or Fallout 1. At beginning the absolute mouse works fine, but when I’ll arrived to door where main character says “Hello! Anybody at home?” and I tap on door then is cursor moved to lower bottom part of screen. The game must report to MS-DOS new cursor location with interrupts, but this does not happens. This makes absolute mouse desynchronisation. Special widget configured to “Mouse reset” helps until game itself moves cursor to new location.
You have to play this game with relative mouse. Try set mouse sensitivty to 200 or so, so relative mouse will run faster. It’s well playable.